Drug Metabolism Handbook : Concepts and Applications - neues Buch

EAN (ISBN-13): 9780470439258
ISBN (ISBN-10): 0470439254
Erscheinungsjahr: 2009
Herausgeber: Wiley
800 Seiten
Sprache: eng/Englisch

Buch in der Datenbank seit 2010-05-16T03:34:58+02:00 (Berlin)
Detailseite zuletzt geändert am 2023-02-12T18:22:42+01:00 (Berlin)
ISBN/EAN: 0470439254

ISBN - alternative Schreibweisen:
0-470-43925-4, 978-0-470-43925-8
Alternative Schreibweisen und verwandte Suchbegriffe:
Autor des Buches: eke norbert
Titel des Buches: applications concepts, concepts handbook, metabolism

---

Daten vom Verlag:

Autor/in: Ala F. Nassar
Titel: Drug Metabolism Handbook - Concepts and Applications
Verlag: Wiley; John Wiley & Sons
800 Seiten
Erscheinungsjahr: 2009-03-26
Sprache: Englisch
193,99 € (DE)
Not available (reason unspecified)

EA; E107; E-Book; Nonbooks, PBS / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Analytical Chemistry; Analytische Chemie; Chemie; Chemistry; Drug Discovery & Development; Medical Science; Medizin; Pharmacology & Pharmaceutical Medicine; Pharmakologie u. Pharmazeutische Medizin; Wirkstoffforschung u. -entwicklung; Analytische Chemie; Wirkstoffforschung u. -entwicklung; Pharmakologie u. Pharmazeutische Medizin; BB

Preface. List of Contributors. Part I: Introduction. 1. Historical Perspective (Roberta S. King). 2. Factors Affecting Metabolism (Roberta S. King). 3. Biotransformation sin Drug Metabolism (Roberta S. King). 4.In Vivo Metabolite Kinetics (Zheng Yang). 5. Pharmacogenetics and Pharmacogenomics (Lilian G. Yengi). 6. Introduction to drug transporters (Louis Leung and AramOganesian). Part II: Technologies for In Vitro and In VivoStudies. 7. Automated Drug Screening for ADMET Properties (MelvinReichman and Helen Gill). 8. Mass Spectrometry (Thomas R. Sharp). 9. Approaches to Performing Metabolite Elucidation: One Key toSuccess in Drug Discovery and Development (Ala F. Nassar). 10. Structural Modifications of Drug Candidates: How Useful AreThey in Improving Metabolic Stability of New Drugs? Part I:Enhancing Metabolic Stability (Ala F. Nassar). 11. Structural Modifications of Drug Candidates: How Useful AreThey in Improving PK Parameters of New Drugs? Part II: Drug DesignStrategies (Ala F. Nassar). 12. Minimizing the Potential for Drug bioactivation of drugCandidates to Success in Clinical Development (Ala F. Nassar). 13. Screening for reactive Metabolites Using Genotoxicity Arraysand Enzyme/DNA Biocolloids (James F. Rusling, Eli G. Hvastkovs, andJohn B. Schenkman). Part III: Drug Interactions. 14. Enzyme Inhibition (Paul F. Hellenberg). 15. Evaluating and Predicting Human Cytochrome P450 EnzymeInduction (Michael Sinz, Sean Kim, Stephen Ferguson, and EdwardLeCluyse). 16. An Introduction to Metabolic Reaction Phenotyping (Carl D.Davis and A. David Rodrigues). 17. Nuclear receptor-Mediated Gene Regulation in Drug Metabolism(Hongbing Wang and Wen Xie). 18. Characterization of Cytochrome P450 Mechanism-BasedInhibition (Dan Rock and Larry C. Wienkers). 19. Clinical Drug-Drug Interactions. 20. Pharmaceutical Excipients in drug-Drug Interaction (ChuanChen and Abu J. M. Sadeque). Part IV: Toxicity. 21. The Role of Drug Metabolism in Toxicity (Carl D. Davis andUmesh M. Hanumegowda). 22. Allergic reactions to Drugs (Mark P. Grillo). 23. Chemical Mechanism in toxicology (Mark P. Grillo). 24. Mechanisms of Reproductive Toxicity (Aileen F. Keating andPatricia B. Hoyer). 25. An Introduction to Toxicogenomics (Aaron L. Vollrath andChristopher A. Bradfield). 26. Role of Bioactivation Reactions in Chemically InducedNephrotoxicity (Lawrence H. Lash). Part V: Regulatory Perspectives. 27. Drug Metabolism in regulatory Guidances, clinical trials,and Product Labeling (Mark N. Milton). Index.