Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics - Erstausgabe

Containing the latest findings on the toxicity of a wide range of chemotherapeutic agents, this up-to-the-minute reference offers expert analyses on the pharmacokinetic-pharmacodynamic and pharmacokinetic-toxicodynamic relationships of anticancer compounds. Anticancer Drug Toxicity 7explores therapeutic drug monitoring (TDM) as a method of maximizing the efficacy, and minimizing the dangers, of chemotherapy 7presents a vast amount of clinical pharmacokinetic data on cytostatic drugs 7offers a comprehensive classification of toxicity patterns associated with the use of cytotoxic drugs 7analyzes the pharmacokinetics of alkylating agents, platinum compounds, anthracyclines, antimetabolites, semisynthetic podophyllotoxin- and camptothecin derivatives, mitotic inhibitors, and other cytotoxic agents 7highlights the pharmacogenetics of 6-mercaptopurine and its clinical significance 7explicates toxicity in relation to the lungs, kidneys, heart, and gonads 7examines disorders caused by asparaginase preparations 7reviews types of secondary malignancy such as leukemias, ovarian cancer, testicular cancer, breast cancer, secondary solid neoplasias, and Hodgkin's disease 7clarifies the understanding of toxicity as a crucial element in supportive management of cancer therapy 7and more! An enormously practical guide for everyday clinical practice, as well as a source of inspiration for further research in the field, Anticancer Drug Toxicity is an invaluable reference for clinical and medical oncologists; hospital, industrial, and clinical pharmacologists and pharmacists; toxicologists; pharmaceutical chemists; radiologists; and graduate and medical school students in these disciplines.