Uptake and Trafficking of Protein Toxins - Taschenbuch

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ISBN/EAN: 3319865021

ISBN - alternative Schreibweisen:
3-319-86502-1, 978-3-319-86502-7
Alternative Schreibweisen und verwandte Suchbegriffe:
Autor des Buches: barth
Titel des Buches: traffic

Daten vom Verlag:

Autor/in: Holger Barth
Titel: Current Topics in Microbiology and Immunology; Uptake and Trafficking of Protein Toxins
Verlag: Springer; Springer International Publishing
256 Seiten
Erscheinungsjahr: 2018-08-30
Cham; CH
Gedruckt / Hergestellt in Niederlande.
Sprache: Englisch
171,19 € (DE)
175,99 € (AT)
189,00 CHF (CH)
POD
VII, 256 p.

BC; Hardcover, Softcover / Biologie/Mikrobiologie; Mikrobiologie und Virologie; Verstehen; Bordetella pertussis; Botulinum neurotoxins; Clostridium difficile; Clostridium perfringens toxin; Anthrax toxins; Binary actin -ADP-ribosylating toxins; infectious diseases; Medical Microbiology; Pharmacology; Diseases; Pharmakologie; Krankheiten und Störungen; BB

toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists.

Receptor-binding and up-take of binary actin-ADP-ribosylating toxins.- Clostridial Binary Toxins: Basic Understandings that Include Cell-Surface Binding and an Internal “Coup de Grace”.- Host cell chaperones Hsp70/Hsp90 and peptidyl-prolyl cis/trans isomerases are required for the membrane translocation of bacterial ADP-ribosylating toxins.- Multivalent Inhibitors of Channel-Forming Bacterial Toxins.- Toxin Transport by A-B Type of Toxins in Eukaryotic Target Cells and its inhibition by Positively Charged Heterocyclic Molecules.

Holger Barth

Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Albert-Einstein-Allee 11, 89081 Ulm, Germany, e-mail: holger.barth@uni-ulm.de

toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists.