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2017, ISBN: 9811032319
Gebundene Ausgabe
[EAN: 9789811032318], Neubuch, [PU: Springer Verlag, Singapore, Singapore], Hardcover. This volume provides the reader with an overview of the diverse functions of the RUNX family of gene… Mehr…
2017, ISBN: 9811032319
[EAN: 9789811032318], Neubuch, [PU: Springer Nature Singapore Mrz 2017], BIOCHEMIE; CHEMIE / FORSCHUNG (MEDIZINISCH, PSYCHOLOGISCH); ERBLEHRE; GENETIK; GENETIK HUMANGENETIK; HEILKUNDE; HU… Mehr…
2017
ISBN: 9789811032318
[ED: Hardcover], [PU: Springer / Springer Nature Singapore / Springer, Berlin], This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As h… Mehr…
2023, ISBN: 9789811032318
[ED: Buch], [PU: Springer Nature Singapore], Neuware - This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introdu… Mehr…
ISBN: 9789811032318
This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other … Mehr…
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This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy.
The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both ‘gatekeepers’ that modulate p53 responses and ‘caretakers’ that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV.
At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy.
This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immun
Detailangaben zum Buch - RUNX Proteins in Development and Cancer (Advances in Experimental Medicine and Biology, 962, Band 962)
EAN (ISBN-13): 9789811032318
ISBN (ISBN-10): 9811032319
Gebundene Ausgabe
Erscheinungsjahr: 2017
Herausgeber: Groner, Yoram, Ito, Yoshiaki, Liu, Paul, Neil, James C. Speck, Nancy A. van Wijnen, Andre, Springer
Buch in der Datenbank seit 2017-06-06T22:27:20+02:00 (Berlin)
Detailseite zuletzt geändert am 2024-03-21T14:17:02+01:00 (Berlin)
ISBN/EAN: 9789811032318
ISBN - alternative Schreibweisen:
981-10-3231-9, 978-981-10-3231-8
Alternative Schreibweisen und verwandte Suchbegriffe:
Autor des Buches: paul speck, andré paul, ito, wijnen, james liu, groner
Titel des Buches: advances experimental medicine and biology
Daten vom Verlag:
Autor/in: Yoram Groner; Yoshiaki Ito; Paul Liu; James C. Neil; Nancy A. Speck; Andre van Wijnen
Titel: Advances in Experimental Medicine and Biology; RUNX Proteins in Development and Cancer
Verlag: Springer; Springer Singapore
515 Seiten
Erscheinungsjahr: 2017-03-23
Singapore; SG
Gedruckt / Hergestellt in Niederlande.
Sprache: Englisch
213,99 € (DE)
219,99 € (AT)
236,00 CHF (CH)
POD
XX, 515 p. 98 illus., 92 illus. in color.
BB; Hardcover, Softcover / Medizin/Klinische Fächer; Genetik, Medizin; Verstehen; CBFb; DNA damage response; RUNX; epigenetic memory; lineage-specific developmental regulators; Medical Genetics; Oncology; Protein Biochemistry; Onkologie; Biochemie; EA; BC
genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy.
genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV.
At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy.
This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists.
RUNX RUNX1 CBFB RUNXgenes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy.
are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV.
At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy.
This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists.
RUNX RUNX1 CBFBProvides readers with an overview of the diverse functions of the RUNX family genes Is a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists Edited and written by leading scientists from the field
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