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Modeling Dose-response Microarray Data in Early Drug Development Experiments Using R / Order Restricted Analysis of Microarray Data / Dan Lin (u. a.) / Taschenbuch / Use R! / Englisch / 2012 - Lin, Dan
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Lin, Dan:

Modeling Dose-response Microarray Data in Early Drug Development Experiments Using R / Order Restricted Analysis of Microarray Data / Dan Lin (u. a.) / Taschenbuch / Use R! / Englisch / 2012 - Taschenbuch

2012, ISBN: 9783642240065

[ED: Taschenbuch], [PU: Springer Berlin], This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for e… Mehr…

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Modeling Dose-response Microarray Data in Early Drug Development Experiments Using R  Order Restricted Analysis of Microarray Data  Dan Lin (u. a.)  Taschenbuch  Use R!  Englisch  2012 - Lin, Dan
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Lin, Dan:

Modeling Dose-response Microarray Data in Early Drug Development Experiments Using R Order Restricted Analysis of Microarray Data Dan Lin (u. a.) Taschenbuch Use R! Englisch 2012 - Taschenbuch

2012, ISBN: 9783642240065

[ED: Taschenbuch], [PU: Springer Berlin], This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for e… Mehr…

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Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R Order-Restricted Analysis of Microarray Data - Lin, Dan, Ziv Shkedy und Daniel Yekutieli
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Lin, Dan, Ziv Shkedy und Daniel Yekutieli:
Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R Order-Restricted Analysis of Microarray Data - Taschenbuch

2012

ISBN: 3642240062

[EAN: 9783642240065], Gebraucht, sehr guter Zustand, [SC: 0.0], [PU: Springer Berlin], GENE EXPRESSION,ESTIMATION AND INFERENCE UNDER ORDER RESTRICTIONS,DOSE-RESPONSE MICROARRAY DATA,R,, … Mehr…

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Lin, Dan, Ziv Shkedy und Daniel Yekutieli:
Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R Order-Restricted Analysis of Microarray Data 2012 - gebrauchtes Buch

2012, ISBN: 9783642240065

2012 Buchschnitt verkürzt - Gebrauchs- und Lagerspuren - Auflage 2012 11053375/13 Versandkostenfreie Lieferung Gene expression,Estimation and inference under order restrictions,Dose-respo… Mehr…

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Dan Lin; Ziv Shkedy; Daniel Yekutieli; Dhammika Amaratunga; Luc Bijnens:
Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R - Taschenbuch

2012, ISBN: 9783642240065

Order-Restricted Analysis of Microarray Data, Buch, Softcover, 2012, [PU: Springer Berlin], Springer Berlin, 2012

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Bibliographische Daten des bestpassenden Buches

Details zum Buch
Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze this data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students. Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as inference under order restrictions and non-linear parametric models, which are used in the second part of the book. Part II is the core of the book, in which we focus on the analysis of dose-response microarray data. Methodological topics discussed include: * Multiplicity adjustment * Test statistics and procedures for the analysis of dose-response microarray data * Resampling-based inference and use of the SAM method for small-variance genes in the data * Identification and classification of dose-response curve shapes * Clustering of order-restricted (but not necessarily monotone) dose-response profiles * Gene set analysis to facilitate the interpretation of microarray results * Hierarchical Bayesian models and Bayesian variable selection * Non-linear models for dose-response microarray data * Multiple contrast tests * Multiple confidence intervals for selected parameters adjusted for the false coverage-statement rate All methodological issues in the book are illustrated using real-world examples of dose-response microarray datasets from early drug development experiments.

Detailangaben zum Buch - Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R


EAN (ISBN-13): 9783642240065
ISBN (ISBN-10): 3642240062
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2012
Herausgeber: Springer Berlin
282 Seiten
Gewicht: 0,460 kg
Sprache: Englisch

Buch in der Datenbank seit 2008-01-21T04:42:58+01:00 (Berlin)
Detailseite zuletzt geändert am 2022-09-26T13:43:04+02:00 (Berlin)
ISBN/EAN: 9783642240065

ISBN - alternative Schreibweisen:
3-642-24006-2, 978-3-642-24006-5
Alternative Schreibweisen und verwandte Suchbegriffe:
Autor des Buches: luc, dhammika, case, lin
Titel des Buches: dose, analysis use, dos, experiments experiment, döse, development, lin


Daten vom Verlag:

Autor/in: Dan Lin; Ziv Shkedy; Daniel Yekutieli; Dhammika Amaratunga; Luc Bijnens
Titel: Use R! Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R - Order-Restricted Analysis of Microarray Data
Verlag: Springer; Springer Berlin
282 Seiten
Erscheinungsjahr: 2012-08-26
Berlin; Heidelberg; DE
Gedruckt / Hergestellt in Niederlande.
Sprache: Englisch
53,49 € (DE)
54,99 € (AT)
59,00 CHF (CH)
POD
XV, 282 p. 96 illus., 4 illus. in color.

BC; Hardcover, Softcover / Mathematik/Wahrscheinlichkeitstheorie, Stochastik, Mathematische Statistik; Wahrscheinlichkeitsrechnung und Statistik; Verstehen; Dose-response microarray data; Estimation and inference under order restrictions; Gene expression; R; Statistics; Statistics and Computing; Pharmaceutics; Biostatistics; Bioinformatics; Computational and Systems Biology; Mathematische und statistische Software; Medizinische Chemie, Pharmazeutische Chemie; DV-gestützte Biologie/Bioinformatik; EA

All methodological issues in the book are illustrated using four “real-world” examples of dose-response microarray datasets from early drug development experiments.
This book focuses on the analysis of microarray data in the dose-response setting in early drug development experiments in the pharmaceutical industry Part I discusses the dose-response setting and the problem of estimation of normal means under order restrictions Part II demonstrates the use of the IsoGene R library and in particular its graphical capacity

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