Drug Delivery Strategies for Poorly Water-Soluble Drugs - gebunden oder broschiert

EAN (ISBN-13): 9780470711972
ISBN (ISBN-10): 0470711973
Gebundene Ausgabe
Erscheinungsjahr: 2013
Herausgeber: John Wiley & Sons Inc

Buch in der Datenbank seit 2013-06-08T12:35:34+02:00 (Berlin)
Detailseite zuletzt geändert am 2024-03-03T18:46:04+01:00 (Berlin)
ISBN/EAN: 9780470711972

ISBN - alternative Schreibweisen:
0-470-71197-3, 978-0-470-71197-2
Alternative Schreibweisen und verwandte Suchbegriffe:
Autor des Buches: dionysios, alfred, fahr
Titel des Buches: poor, wat, drug delivery, drugs, del sol

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Daten vom Verlag:

Autor/in: Dionysios Douroumis; Alfred Fahr
Titel: Advances in Pharmaceutical Technology; Drug Delivery Strategies for Poorly Water-Soluble Drugs
Verlag: Wiley; John Wiley & Sons
626 Seiten
Erscheinungsjahr: 2013-01-25
Gewicht: 1,230 kg
Sprache: Englisch
159,00 € (DE)
Not available (reason unspecified)
175mm x 250mm x 40mm

BB; Hardcover, Softcover / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Biopolymere; Biopolymers; Chemie; Chemistry; Drug Formulation & Delivery; Industrial Chemistry; Polymer Science & Technology; Polymerwissenschaft u. -technologie; Technische u. Industrielle Chemie; Wirkstoffformulierung, Wirkstofftransport; Wirkstofffreisetzung; Technische u. Industrielle Chemie; Wirkstoffformulierung, Wirkstofftransport; Biopolymere

List of Contributors xvii Series Preface xxi Preface xxiii 1 Self-Assembled Delivery Vehicles for Poorly Water-Soluble Drugs: Basic Theoretical Considerations and Modeling Concepts 1 Sylvio May and Alfred Fahr 1.1 Introduction 1 1.2 Brief Reminder of Equilibrium Thermodynamics 3 1.3 Principles of Self-Assembly in Dilute Solutions 7 1.4 Solubility and Partitioning of Drugs 11 1.5 Ways to Model Interactions in Colloidal Systems 16 1.6 Kinetics of Drug Transfer from Mobile Nanocarriers 23 1.7 Conclusion 29 2 Liposomes as Intravenous Solubilizers for Poorly Water-Soluble Drugs 37 Peter van Hoogevest, Mathew Leigh and Alfred Fahr 2.1 Introduction 37 2.2 Intravenous Administration of Poorly Water-Soluble Compounds (PWSC) 40 2.3 Conclusion 59 3 Drug Solubilization and Stabilization by Cyclodextrin Drug Carriers 67 Thorsteinn Loftsson and Marcus E. Brewster 3.1 Introduction 67 3.2 Structure and Physiochemical Properties 68 3.3 Cyclodextrin Complexes and Phase Solubility Diagrams 72 3.4 Cyclodextrin Complexes 76 3.5 Effects on Drug Stability 77 3.6 Cyclodextrins and Drug Permeation through Biological Membranes 80 3.7 Drug Solubilization in Pharmaceutical Formulations 82 3.8 Toxicology and Pharmacokinetics 89 3.9 Regulatory Issues 90 3.10 Conclusion 91 4 Solid Lipid Nanoparticles for Drug Delivery 103 Sonja Joseph and Heike Bunjes 4.1 Introduction 103 4.2 Preparation Procedures for Solid Lipid Nanoparticles 104 4.3 Structural Parameters and Their Influence on Product Quality and Pharmaceutical Performance 116 4.4 Incorporation of Poorly Soluble Drugs and In Vitro Release 123 4.5 Safety Aspects, Toxicity and Pharmacokinetic Profiles 129 4.6 Conclusion 133 5 Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs 151 Naveed Ahmed, C.E. Mora-Huertas, Chiraz Jaafar-Maalej, Hatem Fessi and Abdelhamid Elaissari 5.1 Introduction 151 5.2 Safety and Biocompatibility of Polymers 152 5.3 Encapsulation Techniques of Hydrophobic Drugs 156 5.4 Behavior of Nanoparticles as Drug Delivery Systems 173 5.5 Conclusion 177 6 Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs 199 Dagmar Fischer 6.1 Introduction 199 6.2 Drug Encapsulation by Monomer Polymerization 200 6.3 Polymeric Nanospheres and Nanocapsules Produced by Polymerization 209 6.4 Formulation Components 210 6.5 Control of Particle Morphology 212 6.6 Toxicity and In Vivo Performance 213 6.7 Scale-Up Considerations 214 6.8 Conclusion 217 7 Development of Self-Emulsifying Drug Delivery Systems (SEDDS) for Oral Bioavailability Enhancement of Poorly Soluble Drugs 225 Dimitrios G. Fatouros and Anette Mullertz 7.1 Introduction 225 7.2 Lipid Processing and Drug Solubilization 226 7.3 Self-Emulsifying Drug Delivery Systems 227 7.4 In Vitro Digestion Model 232 7.5 Enhancement of Oral Absorption by SEDDS 235 7.6 Conclusion 238 8 Novel Top-Down Technologies: Effective Production of Ultra-Fine Drug Nanocrystals 247 C.M. Keck, S. Kobierski, R. Mauludin and R.H. Muller 8.1 Introduction: General Benefits of Drug Nanocrystals (First Generation) 247 8.2 Ultra-Fine Drug Nanocrystals ( 8.3 Production of First Generation Nanocrystals: A Brief Overview 250 8.4 Production of Ultra-Fine Drug Nanocrystals: Smartcrystals 252 8.5 Conclusion 259 9 Nanosuspensions with Enhanced Drug Dissolution Rates of Poorly Water-Soluble Drugs 265 Dennis Douroumis 9.1 Introduction 265 9.2 Crystal Growth and Nucleation Theory 266 9.3 Creating Supersaturation and Stable Nanosuspensions 269 9.4 Antisolvent Precipitation Via Mixer Processing 272 9.5 Antisolvent Precipitation by Using Ultrasonication 277 9.6 Nanoprecipitation Using Microfluidic Reactors 278 9.7 Particle Engineering by Spray: Freezing into Liquid 279 9.8 Precipitation by Rapid Expansion from Supercritical to Aqueous Solution 280 9.9 Conclusion 282 10 Microemulsions for Drug Solubilization and Delivery 287 X.Q. Wang and Q. Zhang 10.1 Introduction 287 10.2 Microemulsion Formation and Phase Behavior 289 10.3 HLB, PIT and Microemulsion Stability 293 10.4 Microemulsion Physico-Chemical Characterization 293 10.5 Components of Microemulsion Formulations 295 10.6 Preparation Methods 303 10.7 In Vitro and In Vivo Biological Studies 303 10.8 Recent Developments and Future Directions 314 11 Hot Melt Extrusion: A Process Overview and Use in Manufacturing Solid Dispersions of Poorly Water-Soluble Drugs 325 Shu Li, David S. Jones and Gavin P. Andrews 11.1 Introduction: Present Challenges to Oral Drug Delivery 325 11.2 Solid Drug Dispersions for Enhanced Drug Solubility 327 11.3 Hot Melt Extrusion (HME) as a Drug Delivery Technology 329 11.4 Solubility Enhancement Using HME 340 11.5 Representative Case Studies with Enhanced Solubility 344 11.6 Conclusion 347 12 Penetration Enhancers, Solvents and the Skin 359 Jonathan Hadgraft and Majella E. Lane 12.1 Introduction 359 12.2 Interactions of Solvents and Enhancers with the Skin 360 12.3 Skin Permeation Enhancement of Ibuprofen 363 12.4 Conclusion 369 13 Dendrimers for Enhanced Drug Solubilization 373 Narendra K. Jain and Rakesh K. Tekade 13.1 Introduction 373 13.2 Current Solubilization Strategies 374 13.3 Origin of Dendrimers 374 13.4 What Are Dendrimers? 375 13.5 Synthesis of Dendritic Architecture 375 13.6 Structure and Intrinsic Properties of Dendrimeric Compartments 377 13.7 Dendrimers in Solubilization 378 13.8 Factors Affecting Dendrimer-Mediated Solubilization and Drug Delivery 381 13.9 Drug-Dendrimer Conjugation Approaches 386 13.10 Dendrimers' Biocompatibility and Toxicity 393 13.11 Classification of PEGylated Dendrimers 394 13.12 Conclusion 399 14 Polymeric Micelles for the Delivery of Poorly Soluble Drugs 411 Swati Biswas, Onkar S. Vaze, Sara Movassaghian and Vladimir P. Torchilin 14.1 Micelles and Micellization 411 14.2 Chemical Nature and Formation Mechanism of Polymeric Micelles 416 14.3 Polymeric Micelles: Unique Nanomedicine Platforms 419 14.4 Determination of Physico-Chemical Characteristics of Polymeric Micelles 430 14.5 Drug Loading 435 14.6 Biodistribution and Toxicity 439 14.7 Targeting Micellar Nanocarriers: Example: Drug Delivery to Tumors 443 14.8 Site-Specific Micellar-Drug Release Strategies 449 14.9 Intracellular Delivery of Micelles 452 14.10 Multifunctional Micellar Nanocarriers 453 14.11 Conclusion 455 15 Nanostructured Silicon-Based Materials as a Drug Delivery System for Water-Insoluble Drugs 477 Vesa-Pekka Lehto, Jarno Salonen, H´elder A. Santos and Joakim Riikonen 15.1 Introduction 477 15.2 Control of Particle Size and Pore Morphology 478 15.3 Surface Functionalization 482 15.4 Biocompatibility and Cytotoxicity 485 15.5 Nanostructured Silicon Materials as DDS 492 15.6 Conclusion 502 16 Micro- and Nanosizing of Poorly Soluble Drugs by Grinding Techniques 509 Stefan Scheler 16.1 Introduction 509 16.2 Kinetics of Drug Dissolution 510 16.3 Micronization and Nanosizing of Drugs 510 16.4 Theory of Grinding Operations 512 16.5 Influence of the Stabilizer 520 16.6 Milling Equipment and Technology 527 16.7 Process Development from Laboratory to Commercial Scale 535 16.8 Application and Biopharmaceutical Properties 537 16.9 Conclusion 543 17 Enhanced Solubility of Poorly Soluble Drugs Via Spray Drying 551 Cordin Arpagaus, David R¨utti and Marco Meuri 17.1 Introduction 551 17.2 Advantages of Spray Drying 553 17.3 Principles and Instrumentation of Spray Drying Processes 553 17.4 Optimizing Spray Drying Process Parameters 563 17.5 Spray Drying of Water-Insoluble Drugs: Case Studies 566 17.6 Conclusion 582 References 583 Index 587