ISBN: 9780387848341

alfunctiontoprovidethebioenergetic/synthetic/growthrequirementsforthep- gression of the neoplastic cell to malignancy. In the absence of the metabolic transformation,theneoplasticmalignan… Mehr…

alfunctiontoprovidethebioenergetic/synthetic/growthrequirementsforthep- gression of the neoplastic cell to malignancy. In the absence of the metabolic transformation,theneoplasticmalignantcellwillnotachieveitsmalignantpot- tial. Thus,itiscriticaltoestablishtheroleofthemitochondriainthemalignant process. Moreover,speci?calterationsindifferentcancertypesmustbeidenti?ed. Such information will provide new approaches to the treatment and perhaps preventionofdifferingcancers. TheadventofMetabolomicsforthedetectionof v vi Preface cancer and progression of malignancy is dependent upon the elucidation and identi?cationofalteredmetabolismandmitochondrialfunction. Thus,thisexciting journeyincancerresearchhasbarelybegunandhasalongwaytogo. Thisbook, Mitochondria and Cancer, and its subject matter provide a roadmap and the preparationtoproceedonthisjourney. Wearegreatlyindebtedtothecontributingauthorsfortheirenthusiasticsupport andwritingachapterintheirareaofexpertise. WearegratefultoMs. DonnaOvak for secretarial help and our families for their patience and support in putting togetherthisbook. Thisbookisdedicatedtopast,present,andfuture´´mitoch- driacs´´aroundtheworld. Buffalo,NY KeshavK. Singh Baltimore,MD LeslieC. Costello Contents MitochondriaandCancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 KjerstinM. Owens,J. S. Modica-Napolitano,andKeshavK. Singh WarburgandhisLegacy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 MichaelRistowandTimJ. Schulz TheLipogenicSwitchinCancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 KoenBrusselmansandJohannesV. Swinnen CitrateMetabolisminProstateandOtherCancers . . . . . . . . . . . . . . . . . . . . . . . . . 61 RentyB. FranklinandLeslieC. Costello IntegrationofGenetic,Proteomic,andMetabolicApproachesin TumorCellMetabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 LeslieC. CostelloandRentyB. Franklin MitochondrialRespirationandDifferentiation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 RobertoScatena,PatriziaBottoni,andBrunoGiardina IntegrationofEnergyMetabolismandControlofApoptosis inTumorCells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103 JohnG. PastorinoandJanB. Hoek EnergyGeneratingPathwaysandtheTumorSuppressorp53 . . . . . . . . . . . 131 ChadA. Corcoran,YingHuang,andM. SaeedSheikh MitochondrialTumorSuppressors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151 BoraE. Baysal MitochondriainHematology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163 StefanieZanssen vii viii Contents MitochondriaandOncocytomas. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 193 J. Lima,V. Ma¿ximo,P. Soares,R. Portugal,S. Guimara~es, andM. Sobrinho-Simo~es MitochondriaasTargetsforCancerTherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211 StephenJ. RalphandJiriNeuzil ReversingtheWarburgEffect:MetabolicModulationasa NovelCancerTherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 251 GopinathSutendraandEvangelosD. Michelakis MitochondrialNanotechnologyforCancerTherapy . . . . . . . . . . . . . . . . . . . . . . 265 VolkmarWeissig,GerardG. M. D´Souza,Shing-MingCheng, andSarathiBoddapati Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281 Contributors BoraE. Baysal DepartmentofPathology,YaleUniversitySchoolofMedicine,310CedarStreet, NewHaven,CT06520-8023,USA,bora. baysal@yale. edu SarathiBoddapati Department of Pharmaceutical Sciences, Midwestern University College of PharmacyGlendale,Glendale,AZ,USA PatriziaBottoni DipartimentodiMedicinadiLaboratorio,Universita` CattolicadelSacroCuore, LargoA. Gemelli8,00168Rome,Italy KoenBrusselmans LaboratoryforExperimentalMedicineandEndocrinology,KatholiekeUniversiteit Leuven,Leuven,Belgium Shing-MingCheng Department of Pharmaceutical Sciences, Midwestern University College of PharmacyGlendale,Glendale,AZ,USA ChadA. An exhaustive analysis of the role of mitochondria in cancer, this book surveys the Warburg Hypothesis, mitochondrial structure and function, and then outlines the metabolic and molecular alterations in mitochondria that are associated with human cancer. Buch (fremdspr.) Bücher>Fremdsprachige Bücher>Englische Bücher, Springer Verlag GmbH<

ISBN: 9780387848341

An exhaustive analysis of the role of mitochondria in cancer, this book surveys the Warburg Hypothesis, mitochondrial structure and function, and then outlines the metabolic and molecular… Mehr…

An exhaustive analysis of the role of mitochondria in cancer, this book surveys the Warburg Hypothesis, mitochondrial structure and function, and then outlines the metabolic and molecular alterations in mitochondria that are associated with human cancer. alfunctiontoprovidethebioenergetic/synthetic/growthrequirementsforthep- gression of the neoplastic cell to malignancy. In the absence of the metabolic transformation,theneoplasticmalignantcellwillnotachieveitsmalignantpot- tial. Thus,itiscriticaltoestablishtheroleofthemitochondriainthemalignant process. Moreover,speci?calterationsindifferentcancertypesmustbeidenti?ed. Such information will provide new approaches to the treatment and perhaps preventionofdifferingcancers. TheadventofMetabolomicsforthedetectionof v vi Preface cancer and progression of malignancy is dependent upon the elucidation and identi?cationofalteredmetabolismandmitochondrialfunction. Thus,thisexciting journeyincancerresearchhasbarelybegunandhasalongwaytogo. Thisbook, Mitochondria and Cancer, and its subject matter provide a roadmap and the preparationtoproceedonthisjourney. Wearegreatlyindebtedtothecontributingauthorsfortheirenthusiasticsupport andwritingachapterintheirareaofexpertise. WearegratefultoMs. DonnaOvak for secretarial help and our families for their patience and support in putting togetherthisbook. Thisbookisdedicatedtopast,present,andfuture"mitoch- driacs"aroundtheworld. Buffalo,NY KeshavK. Singh Baltimore,MD LeslieC. Costello Contents MitochondriaandCancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 KjerstinM. Owens,J. S. Modica-Napolitano,andKeshavK. Singh WarburgandhisLegacy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 MichaelRistowandTimJ. Schulz TheLipogenicSwitchinCancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 KoenBrusselmansandJohannesV. Swinnen CitrateMetabolisminProstateandOtherCancers . . . . . . . . . . . . . . . . . . . . . . . . . 61 RentyB. FranklinandLeslieC. Costello IntegrationofGenetic,Proteomic,andMetabolicApproachesin TumorCellMetabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 LeslieC. CostelloandRentyB. Franklin MitochondrialRespirationandDifferentiation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 RobertoScatena,PatriziaBottoni,andBrunoGiardina IntegrationofEnergyMetabolismandControlofApoptosis inTumorCells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103 JohnG. PastorinoandJanB. Hoek EnergyGeneratingPathwaysandtheTumorSuppressorp53 . . . . . . . . . . . 131 ChadA. Corcoran,YingHuang,andM. SaeedSheikh MitochondrialTumorSuppressors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151 BoraE. Baysal MitochondriainHematology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163 StefanieZanssen vii viii Contents MitochondriaandOncocytomas. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 193 J. Lima,V. Ma¿ximo,P. Soares,R. Portugal,S. Guimara~es, andM. Sobrinho-Simo~es MitochondriaasTargetsforCancerTherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211 StephenJ. RalphandJiriNeuzil ReversingtheWarburgEffect:MetabolicModulationasa NovelCancerTherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 251 GopinathSutendraandEvangelosD. Michelakis MitochondrialNanotechnologyforCancerTherapy . . . . . . . . . . . . . . . . . . . . . . 265 VolkmarWeissig,GerardG. M. D'Souza,Shing-MingCheng, andSarathiBoddapati Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281 Contributors BoraE. Baysal DepartmentofPathology,YaleUniversitySchoolofMedicine,310CedarStreet, NewHaven,CT06520-8023,USA,bora. baysal@yale. edu SarathiBoddapati Department of Pharmaceutical Sciences, Midwestern University College of PharmacyGlendale,Glendale,AZ,USA PatriziaBottoni DipartimentodiMedicinadiL Bücher / Fremdsprachige Bücher / Englische Bücher 978-0-387-84834-1, Springer Verlag GmbH<

ISBN: 9780387848341

Biomedicine; Cancer Research; Medical Microbiology; Molecular Medicine; Cell Biology; Biomedicine general; Laboratory Medicine Citrate Metabolism, Lipogenic Switch, Mitochondria, Mitochon… Mehr…

Biomedicine; Cancer Research; Medical Microbiology; Molecular Medicine; Cell Biology; Biomedicine general; Laboratory Medicine Citrate Metabolism, Lipogenic Switch, Mitochondria, Mitochondrial Nanotechnology, Mitochondrial Respiration, Oncocytomas, Prostate Cancer, Proteomics, Warburg, apoptosis, tumorigenesis Books Book, Springer Science+Business Media<

ISBN: 9780387848341

An exhaustive analysis of the role of mitochondria in cancer, this book surveys the Warburg Hypothesis, mitochondrial structure and function, and then outlines the metabolic and molecular… Mehr…

An exhaustive analysis of the role of mitochondria in cancer, this book surveys the Warburg Hypothesis, mitochondrial structure and function, and then outlines the metabolic and molecular alterations in mitochondria that are associated with human cancer. Science Science eBook, Springer New York<

2008, ISBN: 9780387848341

Hardcover, Buch, [PU: Springer-Verlag New York Inc.]